Maintaining the pH in Its Normal Levels Prevents the Growth of Research Paper

Maintaining the pH in Its Normal Levels Prevents the Growth of Methicillin-Resistant Staphylococcus Aureus - Research Paper Example Methicillin-resistant S. aureus (MRSA), just like other S. aureus strains avoids such immune response through catalase, which efficiently breaks down hydrogen peroxide into water and oxygen. This activity of the catalase in the escape of the host’s immune reaction has been shown in a murine animal model (Das and Bishayi, 2009). What was not mentioned in the primary reference is that what is so distinct about MRSA is the fact that the bacteria cannot be killed by the most common antibiotics, penicillin and cephalosporin groups, characterized by their beta-lactam ring. Briefly, these antibiotics prevent the production of the bacteria’s peptidoglycan-rich cell wall by inhibiting transpeptidation. MRSA contains beta-lactamases that bind to beta-lactams, and render these bactericides inactive (Agrawal, n. d.). Effectiveness of alkaline solution against MRSA infection It has been proposed by Shannon Brown (2010), in his article, â€Å"End of MRSA-How?†, prevention of M RSA infection simply involves avoiding acidic food products and stress, which increases the acid in the digestive tract. According to Brown, the acidic environment allows the normal flora of the gut to die and the acidophilic MRSA to thrive. The solution to a potential MRSA infection is said to lie on increasing the pH of the environment to which it is exposed to. Despite the seemingly simple solution to the problem of MRSA infection, prevention still poses a great challenge as the current food products available in the market are cultivated using acidic fertilizers and pesticides. Many people also enjoy drinking coffee, tea, wine and alcohol, all of which make the gut more acidic. As such, the article suggests that alkaline solutions can prevent uncontrolled MRSA growth in the body. Specifically, taking in pHenomenal, an alkaline water concentrate, as food supplement is said to potentially increase the pH of the digestive tract, and to subsequently prevent MRSA infection. Such acti vity has been shown through an in vitro pH neutralization test, whereby lactic acid was neutralized by pHenomenal at approximately 1:22 acid-to-pHenomenal ratio. Another alkaline product suggested to prevent MRSA infection is B-pHree, which can be applied on the skin, where MRSA normally resides. In an antibacterial efficacy assay done on this substance, it was found that it effectively inhibited the growth (100% growth reduction) of Staphylococcus aureus inoculated in Tryptic Soy Agar (TSA) incubated for 24 hours. Despite the promise of MRSA prevention and the availability of prophylactic measures, there are potential problems regarding the claims of preventing bacterial infection by increasing the pH in the gut. Literature review Normally, the stomach is highly acidic, with pH of approximately 2. This acidity is a strategy to control the activity of pepsin, which catalyzes the breakdown of proteins into organic compounds that can be used by the body in its various physiologic proc esses. In addition, the highly acidic environment of the stomach prevents the growth of most pathogens that cannot thrive in such extreme conditions. In fact, it has been shown by Suzuki (1994) that the low pH of gastric pH is directly related to decreased amounts of pathogenic bacteria such as Staphylococcus and MRSA in the gut. In addition, it was found that cancer patients before and after operation, who have high levels of gastric pH are more likely to have Staphylococcus and MRSA in the gut. Although the in vitro experiments have both supported

Effects of coffee Essay Example | Topics and Well Written Essays - 750 words

Effects of coffee - Essay Example Coffee contains caffeine which is considered a Central Nervous System (CNS) stimulant (Lovett 2005). Accordingly, â€Å"caffeine is the worlds most widely consumed psychoactive substance†. Balentine, Harbowy & Graham (1998) stipulated that â€Å"many natural sources of caffeine also contain widely varying mixtures of other xanthine alkaloids, including the cardiac stimulants theophylline and theobromine and other substances such as polyphenols which can form insoluble complexes with caffeine†. In the Science of Cooking, the article on caffeine exhibited its following properties, to wit: â€Å"soluble in ethyl acetate, chloroform, pyrimidine, pyrrole, tetrahydrofuran solution; moderately soluble in alcohol, acetone; slightly soluble in petroleum ether, ether, benzene†. In another study made specifically on Caffeine, it is found that â€Å"caffeine is metabolized in the liver by the cytochrome P450 oxidase enzyme system (specifically, the 1A2 isozyme) into three metabolic dimethylxanthines, which each have their own effects on the body: Theophylline (4%) Relaxes smooth muscles of the bronchi, and is used to treat asthma. The therapeutic dose of theophylline, however, is many times greater than the levels attained from caffeine metabolism.† (The Pharmacogenetics and Pharmacogenomics Knowledge Base) According to Bolton & Null (1981), the â€Å"precise amount of caffeine necessary to produce effects varies from person to person depending on body size and degree of tolerance to caffeine. It takes less than an hour for caffeine to begin affecting the body and a mild dose wears off in three to four hours. Consumption of caffeine does not eliminate the need for sleep: it only temporarily reduces the sensation of being tired. The International Coffee Organization presented that â€Å"of all the physiological effects of coffee, the best known is that it is a stimulant to the nervous system. One or two cups of